Application Note 183: Kinetic Analysis of NGF-Differentiated PC12 Neuronal Cells on an SPRM Chip
Neuronal cell-based studies are important in drug discovery because many neurological, neurodegenerative, pain, and neurodevelopmental diseases depend on cell specific receptor signaling, neurite formation, synaptic biology, survival pathways, and toxic …
Application Note 182: Label-Free Kinetic Analysis of Anti-TCR Binding to Jurkat T Cells Using Surface Plasmon Resonance Microscopy
Understanding how antibodies interact with cell surface receptors is fundamental to the development of immunotherapies, T-cell engagers, and other biologic drugs. Flow cytometry is widely used to characterize antibody binding …
Application Note 181: In Vitro Characterization of Agonist and Antagonist Peptide Binding Interaction Kinetics to GLP-1R in HEK293T Cells Using SPR Microscopy
The glucagon-like peptide-1 receptor (GLP-1R), a class B G protein-coupled receptor (GPCR), is a validated therapeutic target for type 2 diabetes and obesity owing to its central role in glucose …
Application Note 180: Surface Plasmon Resonance Analysis of Chemically Synthesized Cyclic Malaria Antigen PfAMA1 Domain I Binding to PfRON2
Plasmodium falciparum is responsible for most severe malaria cases, causing over half a million deaths annually. Central to erythrocyte invasion is the interaction between apical membrane antigen 1 (PfAMA1) and …
Application Note 179: Resolving Multiple Kinetic Binding Modes in Complex Biological Systems
Surface Plasmon Resonance Microscopy (SPRM) can directly resolve multiple kinetic binding modes in heterogeneous biological samples by extracting independent sets of kinetic parameters from spatially defined regions of interest (ROIs). …
Application Note 178: Modality-Dependent Binding to GLP-1R on Live Cells
The glucagon like peptide-1 receptor (GLP-1R) is a class B G-protein-coupled receptor (GPCR) and one of the most therapeutically important targets in metabolic disease. Its activation promotes insulin secretion, reduces …
Application Note 177: Integrated evaluation of payload-, Fc-, and target-mediated mechanisms of ADCs using streamlined complementary platforms
The poster presented by Alpana Prasad of Eurofins DiscoverX during the AACR annual meeting 2026; now available for download. Authors: Alpana Prasad1, Surekha Bonasu1, Radhika Venkatnarayanan1, Jennifer Lin-Jones1, Jane E. …
Application Note 176: On-Cell Kinetic Characterization of Antibody–Drug Conjugates Using Two-Well SPR Microscopy
Antibody-drug conjugates (ADCs) combine the targeting specificity of monoclonal antibodies with potent cytotoxic payloads, enabling selective elimination of diseased cells while limiting systemic toxicity. As the clinical landscape of ADCs …
Application Note 175: Highly Sensitive Detection of hCG Using Graphene Oxide-Based Surface Plasmon Resonance Aptamers
There is a growing need for enhanced diagnostic technologies to provide high sensitivity, selectivity, and reproducibility in biosensors. Human chorionic gonadotropin (hCG), a relevant clinical biomarker linked with fetal defects, …
Application Note 174: Structure-Dependent ECD Anchoring of GLP-1R by Therapeutic Peptides
GLP-1R is a class B GPCR centrally involved in glucose homeostasis, insulin secretion, appetite, and β-cell maintenance and thus stands as one of the most important targets in metabolic disease …