We offer SPR microscopy technology (SPRm 200 series) for cell-based SPR measurements and traditional SPR designs (BI-4500 and BI-2500) to study binding affinity and kinetics of purified proteins.
SPRM 200 SERIES
The Surface Plasmon Resonance (SPR) Microscopy system, which combines optical microscopy with SPR, is a powerful and label-free technology for measuring the binding affinity and kinetics of membrane proteins directly on whole cells in vitro. This integrated approach enables the simultaneous analysis of phenotypic changes via brightfield imaging and molecular interactions through SPR, offering a comprehensive view of cell-surface binding events.
SPR Microscopy has been replacing radioligand binding assays and has become a go-to platform in both pharmaceutical and academic research for studying the interactions of small molecules, peptides, antibodies, and proteins with membrane targets such as GPCRs, ion channels, and other difficult-to-purify membrane proteins. It supports measurements on both fixed and live cells, whether adherent or in suspension.
Thanks to its high spatial resolution (~1 μm), the technology also enables real-time monitoring of nanoparticles, virus and bacterial binding activity, expanding its applications in infectious disease and microbiology research.
BI-4500 SERIES
The 5-channel SPR instrument, when paired with the BI Autosampler, offers an ideal solution for high-throughput assay development, combining efficiency with low operating and maintenance costs. Featuring advanced BI-DirectFlow™ technology—integrated into the BI-4500 system—it ensures precise sample delivery for exceptional binding kinetic measurements. This innovative flow system, together with temperature-controlled SPR detection, provides highly sensitive and reproducible binding responses, even for low immobilization levels and small molecule targets (<100 Daltons).
The system also supports compatibility with electrochemistry and chemical vapor analysis modules, enabling integrated EC-SPR and gas-SPR measurements. These capabilities make it especially well-suited for a wide range of biosensing applications.
BI-2500 SERIES
This 3-channel SPR system is the preferred choice for advanced biosensor research, including cancer biomarker detection, aptamer development, environmental monitoring, and food contamination analysis. Its open-design architecture, combined with integrated electrochemistry and chemical vapor analysis modules, provides a flexible platform with a clear upgrade path for electrochemistry SPR and gas SPR combination studies.