Technical Notes

Technical Note 101: Principle of SPR Detection: Intensity profile and shift of the SPR angle

Principle of SPR Detection: Intensity profile and shift […]

Technical Note 102: SPR Sensitivity and Detection Limit

When selecting a Surface Plasmon Resonance (SPR) instrument, an obvious question to ask is: What is the sensitivity of the instrument? This seemingly simple question does not have a straightforward answer. The confusion is partially due to the fact there is simply no perfect way to define the sensitivity, and also partially due to the inaccurate use of this term by some vendors. This technical note describes some of the most commonly used terms for defining SPR sensitivity. The goal is to provide SPR users with a guideline to determine if a particular definition is useful for his/her application, and to compare different instruments in a meaningful way.

Technical Note 103: Surface Plasmon Resonance v. Quartz Crystal Microbalance

Surface Plasmon Resonance (SPR) and Quartz Crystal Microbalance (QCM) are two powerful label-free detection techniques that are receiving increasing amounts of attention for many applications, ranging from biomedical, electrochemical, and surface studies to chemical- and biosensors. An often-asked question is: Which one is better or more suitable for my applications? This note will discuss the differences between the two techniques and compare some of the key performance parameters, such as sensitivity, response time, detection limit, accuracy, and multiplexity.

Technical Note: 104 – Concepts Behind EC-SPR

Voltametric technique in electrochemical (EC) detection […]


表面等离子体共振(SPR)是一种广泛用于研究生物分子结合的免标记检测技术。 从90年代商品化以来,SPR在仪器 […]

(English) Technical Note: 106 – SPR Microscopy vs Radioligand Binding Analysis