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SPR Microscopy for Detecting GCPR Target Engagement

Drug Discovery Chemistry conference (April 15 2025)

Speakers:
Kris Borzilleri, Principal Scientist, Structural Biology and Molecular Sciences, Pfizer Global R&D, Groton Labs

Key learnings:
– Present highlights of targets evaluated at Pfizer using SPRm 200
– Comparing small molecule binding results vs radioligand, cAMP and functional assays
– Things to consider when interpreting membrane protein binding kinetics